A new culprit in antibacterial resistance: Cysteine persulfide

796950

Sumary of A new culprit in antibacterial resistance: Cysteine persulfide:

  • A joint research project based in Kumamoto University, Japan has developed a new, highly sensitive analytical method that can detect degraded β-lactam antibacterial agents used in the treatment of bacterial infections..
  • With this method, researchers found that reactive sulfur species produced by bacteria degrade and inactivate β-lactam antibiotics..
  • β-lactam antimicrobial agents are very potent because they selectively inhibit bacterial cell wall synthesis and have few side effects on hosts such as humans..
  • These antimicrobial agents have a common structure called the β-lactam ring that is essential for inhibiting cell wall development..
  • Previous studies have reported that hydrogen sulfide (H2S), which bacteria produce during sulfur metabolism, reduces their susceptibility to antimicrobial agents leading to resistance..
  • In this study, researchers examined how this reactive sulfur species is involved in the acquisition of resistance to β-lactam antibiotics..
  • They discovered that β-lactam antibiotics such as penicillin G, ampicillin, and meropenem (carbapenem antibiotics) rapidly lose bactericidal activity when exposed to cysteine persulfide but not with hydrogen sulfide..
  • A detailed study of the reaction between β-lactam antimicrobial agents and cysteine persulfide revealed that the β-lactam ring, which is essential for bactericidal action, decomposes and a sulfur atom is inserted into part of the ring creating carbothioic acid….

Want to know more click here go to source.

From -
Close
Generic selectors
Exact matches only
Search in title
Search in content

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close