Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis

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Sumary of Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis:

  • Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer andimmunological diseases, such asrheumatoid arthritis(RA), psoriasis andmultiple sclerosis(MS)..
  • The authors designed and synthesized a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents..
  • 2-Acrylamidobenzoic acid analog11was identified as the lead compound for structure-activity relationship (SAR) studies..
  • The replacement of thephenyl group with naphthylmoieties improved inhibitory activity significantly to double-digit nanomolar range….

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