Sumary of Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis:
- Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer andimmunological diseases, such asrheumatoid arthritis(RA), psoriasis andmultiple sclerosis(MS)..
- The authors designed and synthesized a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents..
- 2-Acrylamidobenzoic acid analog11was identified as the lead compound for structure-activity relationship (SAR) studies..
- The replacement of thephenyl group with naphthylmoieties improved inhibitory activity significantly to double-digit nanomolar range….