Better trials needed to assess combination therapy for hypothyroidism

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February 23, 2021

3 min read

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Disclosures: Jonklaas reports no relevant financial disclosures. Please see the consensus statement for all other authors’ relevant financial disclosures.

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Three large professional thyroid organizations issued a joint statement calling for new trials of combination therapy to treat hypothyroidism, citing new clinical endpoints and the importance of assessing patient-reported outcomes.

“Even though a large number of trials have already been published, a clear benefit of combination therapy has not been shown,” Jacqueline Jonklaas, MD, PhD, professor of medicine in the division of endocrinology at Georgetown University, told Healio. “Our authors believed that there were sufficient anecdotal data from patients and sufficient new scientific data — both basic science, translational science and clinical science — that the issue deserved to be reconsidered…

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