Candida Auris: An Enigmatic and Difficult-to-Treat Fungal Pathogen

candida auris an enigmatic and difficult to treat fungal pathogen

Sumary of Candida Auris: An Enigmatic and Difficult-to-Treat Fungal Pathogen:

  • The emergence of Candida auris (C auris) was first identified in a single case in Japan where a man had it appear in his ear.
  • According to the Centers for Disease Control and Prevention (CDC), a retrospective review of Candida strain collections found that the earliest known strain of the fungus dated back further to 1996 in South Korea.
  • According to reports, some of these patients infected with C auris did not show any clinical improvement after being treated with all 3 major classes of the antifungals.
  • While C auris does not appear to have a high incidence rate, the infection presents some serious challenges to clinicians.
  • Although C auris fungal infection is still relatively rare, when it occurs in the health care setting, it can quickly take hold and become an outbreak if infection prevention measures are not taken.
  • “The overwhelming majority of Candida auris clinical isolates are resistant to one of the 3 classes of antifungals that we have to treat invasive infections,” Jeffrey Rybak, PharmD, PhD, instructor, Department of Pharmaceutical Sciences, St.
  • Rybak has been conducting research on C auris in trying to Identify novel targets for therapy, apply next-generation sequencing technologies, and develop molecular tools to advance the study of the fungus.

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