Convalescent Plasma Does Not Reduce Risk of Intubation, Mortality

convalescent plasma does not reduce risk of intubation mortality

Sumary of Convalescent Plasma Does Not Reduce Risk of Intubation, Mortality:

  • The clinical trial, called CONCOR-1, stopped enrollment early in January 2021 after its independent data safety monitoring committee recommended the study was unlikely to demonstrate a benefit of convalescent plasma even if more patients were enrolled.
  • A secondary discovery was that convalescent plasma had highly variable donor antibody content due to the highly variable immunological response to the virus.
  • Different antibody profiles in the convalescent plasma were observed to significantly impact whether or not patients experienced intubation or death.

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