Sumary of End of Alzheimer’s: Scientists reverse age-related memory loss in mice:
- Scientists from Cambridge and Leeds have made a ground-breaking discovery after successfully reversing age-related memory loss.
- The researchers say their discovery could lead to the development of treatments to help prevent memory loss in people as they age.
- The study looked at perineuronal nets (PNNs) which are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
- Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory.
- Researchers investigated how a manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.
- To do this, they looked at 20-month-old mice which are considered to be very old and by implementing a suite of tests it was shown the mice exhibited deficits in their memory compared to six-month old mice.