Expert highlights factors to consider in risk assessment for living donors


Sumary of Expert highlights factors to consider in risk assessment for living donors:

  • Improving Global Outcomes, a speaker highlighted several factors to consider when assessing risk for GFR decline in potential donors..
  • “The KDIGO framework utilizes three components for deciding whether to accept or decline a donation [based on the risk posed to the donor],”.
  • “These include donor factors, demographic factors, and a calculation of risk that is associated with the development of [end-stage kidney disease] ESKD in the lifetime of a subject who does not donate a kidney.”.
  • Poggio emphasized that the same GFR cutoffs cannot be used for all potential donors because GFR has different implications for people based on age..
  • “This is an important concept because a GFR of 90 [mL/min/1.73 m2] might not be the same for a younger donor vs..
  • Age, according to Poggio, plays a big role in lower GFR and greater GFR decline after donation, with study findings suggesting younger donor age is associated with better GFR after donation (even after 40 years)..
  • In addition, research shows a family history of ESKD predicts those at greater risk for GFR decline following kidney donation..
  • “The older we are, the less likely we’ll recover kidney function and the more pronounced the drop is if there is a history of kidney disease.”…

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