Sumary of Fountain of youth for aging stem cells in bone marrow:
- One responsible mechanism involves the impaired function of the bone-marrow stem cells, which are required for the maintenance of bone integrity.
- Researchers from the Max Planck Institute for Biology of Ageing and CECAD Cluster of Excellence for Ageing Research at the University of Cologne have now shown that the reduced stem cell function upon ageing is due to changes in their epigenome.
- They were able to reverse these changes in isolated stem cells by adding acetate.
- Ageing Researchers have been looking at epigenetics as a cause of ageing processes for some time.
- One possibility is changes in proteins called histones, which package the DNA in our cells and thus control access to DNA.
- The Cologne research group of Peter Tessarz has now studied the epigenome of mesenchymal stem cells.
- These stem cells are found in bone marrow and can give rise to different types of cells such as cartilage, bone and fat cells.
- “We wanted to know why these stem cells produce less material for the development and maintenance of bones as we age, causing more and more fat to accumulate in the bone marrow.