Heart rate response to sleep apnea events may aid in determining CV benefit from CPAP


Sumary of Heart rate response to sleep apnea events may aid in determining CV benefit from CPAP:

  • Azarbarzin reports support by the American Academy of Sleep Medicine Foundation, American Heart Association and NIH..
  • CPAP therapy may have a protective effect on adverse cardiovascular outcomes in patients with coronary artery disease and nonsleepy obstructive sleep apnea who have greater heart rate responses to sleep apnea events..
  • Greater heart rate response to respiratory events “could be used to select patients most likely to exhibit long-term cardiovascular benefit from CPAP therapy,”.
  • Ali Azarbarzin, PhD, with the division of sleep and circadian disorders at Brigham and Women Hospital and assistant professor of medicine at Harvard Medical School, said during a presentation at the virtual American Thoracic Society International Conference..
  • Previous randomized controlled trials have not detected a protective effect of CPAP therapy on CV outcomes in this patient population, according to the researchers..
  • However, recent analysis of large cohort studies showed that a subgroup of patients with nonsleepy OSA and greater respiratory event-related heart rate response had increased risk for CV events, Azarbarzin said..
  • The researchers determined participants’ heart rates and tested the hypothesis that patients with higher heart rate responses to apneas and hypopneas would have the greatest CV event risk..
  • “If this were true, then we would expect to see a preferential benefit from using CPAP on cardiac outcomes in those with the higher pulse rate response,”…

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