Heart rate response to sleep apnea events may aid in determining CV benefit from CPAP

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Sumary of Heart rate response to sleep apnea events may aid in determining CV benefit from CPAP:

  • Azarbarzin reports support by the American Academy of Sleep Medicine Foundation, American Heart Association and NIH..
  • CPAP therapy may have a protective effect on adverse cardiovascular outcomes in patients with coronary artery disease and nonsleepy obstructive sleep apnea who have greater heart rate responses to sleep apnea events..
  • Greater heart rate response to respiratory events “could be used to select patients most likely to exhibit long-term cardiovascular benefit from CPAP therapy,”.
  • Ali Azarbarzin, PhD, with the division of sleep and circadian disorders at Brigham and Women Hospital and assistant professor of medicine at Harvard Medical School, said during a presentation at the virtual American Thoracic Society International Conference..
  • Previous randomized controlled trials have not detected a protective effect of CPAP therapy on CV outcomes in this patient population, according to the researchers..
  • However, recent analysis of large cohort studies showed that a subgroup of patients with nonsleepy OSA and greater respiratory event-related heart rate response had increased risk for CV events, Azarbarzin said..
  • The researchers determined participants’ heart rates and tested the hypothesis that patients with higher heart rate responses to apneas and hypopneas would have the greatest CV event risk..
  • “If this were true, then we would expect to see a preferential benefit from using CPAP on cardiac outcomes in those with the higher pulse rate response,”…

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