Sumary of How SARS-CoV-2 Evades And Suppresses The Immune System (Part 12):
- CLARY AFP via Getty Images This is the twelfth article in a series called “How SARS-CoV-2 Evades And Suppresses The Immune System,” which will explore an underappreciated but highly significant aspect of SARS-CoV-2 replication.
- The ability of SARS-CoV-2 to delay, evade, and suppress the immune system has myriad implications for drugs, vaccines, and other aspects of our pandemic response.
- Read parts 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11. Ganging up to knock out the key players Interferon is a key player in the innate immune response.
- Its broad effectiveness is contingent on the recruitment of other genes.
- Once activated, many of these interferon-stimulated genes inhibit virus replication directly, whereas others rally the immune system’s second line of defense, the adaptive immune response, into action.
- In Part 11, I examined the left half of the diagram below, which illustrates how SARS-CoV-2 blocks the induction of interferon (see Figure 1).
- We saw how SARS-CoV-2 blockade prevents synthesis of type-I interferons, limiting its action within the cell.
- Should any interferon escape suppression, other factors restrict its exit from the infected cell to alert nearby cells of impending danger.