Sumary of Impaired immune response may cause bone resorption in patients with genetic disorder:
- Researchers at Hiroshima University have discovered the mechanism underlying multifocal osteomyelitis in MSMD patients with poor response to IFN-γ.
- Impaired response to IFN-γ in MSMD patients leads to excessive osteoclast proliferation and, by inference, increases bone resorption in infected foci, which may underlie multifocal osteomyelitis.
- About a quarter of the world’s population is infected with tuberculosis bacteria, according to the World Health Organization, but only about 5 to 10% of those infected will develop symptoms.
- “Multifocal osteomyelitis — bone infection at multiple points — is among the representative manifestations of MSMD,” said Satoshi Okada, professor in the Department of Pediatrics, Hiroshima University’s Graduate School of Biomedical and Health Sciences.
- “However, it is unclear why patients with MSMD frequently develop multifocal osteomyelitis, chronic inflammatory bone diseases.
- ” Now, a team led by Okada has revealed a molecular underpinning of the chronic bone infection in patients with MSMD.
- According to Okada, this finding could lead to better understanding the full immune response and reactions that leads to multifocal osteomyelitis in patients with MSMD.
- “The frequency of multifocal osteomyelitis is especially high in patients with MSMD due to an impaired response to a cell signal called interferon gamma (IFN-γ),” said first author Miyuki Tsumura, research fellow in the Department of Pediatrics, Hiroshima University’s Graduate School of Biomedical and Health Sciences.