Impaired immune response may cause bone resorption in patients with genetic disorder

impaired immune response may cause bone resorption in patients with genetic disorder

Sumary of Impaired immune response may cause bone resorption in patients with genetic disorder:

  • Researchers at Hiroshima University have discovered the mechanism underlying multifocal osteomyelitis in MSMD patients with poor response to IFN-γ.
  • Impaired response to IFN-γ in MSMD patients leads to excessive osteoclast proliferation and, by inference, increases bone resorption in infected foci, which may underlie multifocal osteomyelitis.
  • About a quarter of the world’s population is infected with tuberculosis bacteria, according to the World Health Organization, but only about 5 to 10% of those infected will develop symptoms.
  • “Multifocal osteomyelitis — bone infection at multiple points — is among the representative manifestations of MSMD,” said Satoshi Okada, professor in the Department of Pediatrics, Hiroshima University’s Graduate School of Biomedical and Health Sciences.
  • “However, it is unclear why patients with MSMD frequently develop multifocal osteomyelitis, chronic inflammatory bone diseases.
  • ” Now, a team led by Okada has revealed a molecular underpinning of the chronic bone infection in patients with MSMD.
  • According to Okada, this finding could lead to better understanding the full immune response and reactions that leads to multifocal osteomyelitis in patients with MSMD.
  • “The frequency of multifocal osteomyelitis is especially high in patients with MSMD due to an impaired response to a cell signal called interferon gamma (IFN-γ),” said first author Miyuki Tsumura, research fellow in the Department of Pediatrics, Hiroshima University’s Graduate School of Biomedical and Health Sciences.

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