Implantable sensor based on gold nanoparticles revolutionizes medical diagnostics

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Sumary of Implantable sensor based on gold nanoparticles revolutionizes medical diagnostics:

  • The idea of implantable sensors that continuously transmit information on vital values and concentrations of substances or drugs in the body has fascinated physicians and scientists for a long time..
  • However, until now implantable sensors have not been suitable to remain in the body permanently but had to be replaced after a few days or weeks..
  • Scientists at Johannes Gutenberg University Mainz (JGU) have developed a novel type of implantable sensor which can be operated in the body for several months..
  • The sensor is based on color-stable gold nanoparticles that are modified with receptors for specific molecules..
  • Professor Carsten Sönnichsen’s research group at JGU has been using gold nanoparticles as sensors to detect tiny amounts of proteins in microscopic flow cells for many years..
  • In their study published in Nano Letters, the JGU researchers implanted their gold nanoparticle sensors under the skin of hairless rats..
  • By binding to specific receptors on the surface of the gold nanoparticles, they induce color change that is dependent on drug concentration..
  • Thanks to the color-stable gold nanoparticles and the tissue-integrating hydrogel, the sensor was found to remain mechanically and optically stable over several months..
  • Huge potential of gold nanoparticles as long-lasting implantable medical sensors Related Stories “We are used to colored objects bleaching over time..
  • As they can be easily coated with various different receptors, they are an ideal platform for implantable sensors,”.
  • In future, gold nanoparticle-based implantable sensors could be used to observe concentrations of different biomarkers or drugs in the body simultaneously…

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