‘Just 30 days of glucocorticoid use’ in RA spikes cardiovascular risk by 15% over 6 mont …

just 30 days of glucocorticoid use in ra spikes cardiovascular risk by 15 over 6 months

Sumary of ‘Just 30 days of glucocorticoid use’ in RA spikes cardiovascular risk by 15% over 6 months:

  • November 17, 2021 3 min read Source/Disclosures Published by: Source: Wallace B.
  • ” To examine the incremental impact of glucocorticoid on major adverse cardiac events in RA, Wallace and colleagues conducted a retrospective cohort study of national VA administrative data.
  • Patients were excluded if they were younger than 40 or older than 90 years, or if they had other rheumatic diseases, prior major adverse cardiac event, or congestive heart failure in the previous 5 years.
  • The researchers then used pharmacy data to determine the patients’ supply of glucocorticoids, in days, as well as claims to identify any incidents of major adverse cardiac events.
  • A major event was defined as any acute myocardial infarction, stroke, transient ischemic attack, cardiac arrest or coronary revascularization.
  • Analyses included multilevel logistic regression to evaluate the association between days’ supply of glucocorticoids dispensed in a 6-month period, as well as the lagged outcome of major adverse cardiac events during the subsequent 6 months.
  • Patients were censored after their first major adverse cardiac event.
  • The researchers adjusted data for baseline covariates, including demographics, health care use and long-term glucocorticoid use of more than 90 days.

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