Leptin puts the brakes on eating via novel neurocircuit

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Sumary of Leptin puts the brakes on eating via novel neurocircuit:

  • Now, a new study in mice describes novel neurocircuitry between midbrain structures that control feeding behaviors that are under modulatory control by leptin..
  • John Krystal, MD, Editor of Biological Psychiatry, said of the findings, “Omrani and colleagues shed light on how, in non-obese animals, leptin puts the brakes on overeating.”.
  • Leptin acts as a critical link between the body and the brain, providing information about metabolic state and exerting control over energy balance..
  • Roger Adan, PhD, of the Department of Translational Neuroscience, University Medical Center Utrecht and University Utrecht, the Netherlands, who led the study, said, “This process is shaped by communication between bodily fat storages (via a hormone called leptin) and the brain’s dopamine reward system..
  • This leptin-dopamine axis is critically important for body weight control, but its modes of action were not well understood.”.
  • Leptin suppresses eating by signaling to brain regions that control eating behaviors, but it also decreases the reward value inherent in foods, engaging the brain’s dopamine (DA) reward system..
  • That food-reward pathway was known to involve dopaminergic neurons of the ventral tegmental area (VTA) signaling to the nucleus accumbens (NAc), but most of those DA neurons do not contain receptors for leptin..
  • said Professor Adan, also of the Department of Translational Neuroscience, University Medical Center Utrecht and University Utrecht, “we discovered that leptin receptors are also present on inhibitory neurons that more strongly regulate the activity of dopamine neurons…

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