Like night and day: Animal studies may not translate to humans without time considerations


Sumary of Like night and day: Animal studies may not translate to humans without time considerations:

  • Yet a survey of animal studies across eight behavioral neuroscience domains showed that most behavioral testing is conducted during the day, when the rodents would normally be at rest..
  • Nelson chairs the School of Medicine’s Department of Neuroscience and directs basic science research for the Rockefeller Neuroscience Institute..
  • Nelson and his colleagues — RNI researchers Jacob Bumgarner, William Walker and Courtney DeVries — examined the 25 most frequently cited papers in each of eight categories of rodent behaviors:.
  • Even among the studies conducted at night, most didn’t describe in detail how the authors protected the rodents’ circadian rhythms..
  • And running experiments multiple times — under different conditions — is the basis of all scientific inquiry..
  • “This is important because, in common with the NIH, we want to improve the rigor and reproducibility of science.”.
  • So, how can a diurnal, human researcher design and carry out a study of nocturnal rodents when their circadian rhythms naturally conflict?.
  • This way, she and her colleagues get to observe the animals during their active phase — under simulated “nighttime”…

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