Sumary of LSD-triggered altered behaviors linked to abnormal brain communication:
- Researchers at Baylor College of Medicine have discovered changes in the brain, triggered by the drug, that may explain the profound altered behavior associated with LSD, helping to understand how the brain generates behavior.
- During these altered behaviors, the researchers observed a reduction of the normal communication between the hippocampus and the visual cortex in the brain, which they propose may explain the changed behaviors.
- “Our lab is interested in improving the understanding of how the brain generates behavior,” said corresponding author, Dr. Daoyun Ji, professor of neuroscience at Baylor.
- “LSD triggers abnormal perceptions of the real world and altered behaviors.
- ” Ji and his colleagues took a close look at the animals’ behavior and their simultaneous brain activity with and without LSD, as the rats were running in a familiar C-shaped track.
- To measure the brain activity, the researchers recorded the brain cells’ electrical spiking patterns in real time in two brain areas, the hippocampus, which is important for learning and memory, and the visual cortex.
- “This would give us a measure of what was going on in the brain,” Ji said.
- LSD changes behavior and spiking activity Ji and colleagues found that the animals receiving the drug ran fewer laps and moved slower than those without LSD.