Milvexian helps prevent VTE without raising bleeding after knee arthroplasty

milvexian helps prevent vte without raising bleeding after knee arthroplasty

Sumary of Milvexian helps prevent VTE without raising bleeding after knee arthroplasty:

  • November 15, 2021 2 min read Source/Disclosures Published by: Source: Weitz JI, et al.
  • Presented at: American Heart Association Scientific Sessions;
  • Back to Healio In patients who underwent knee arthroplasty, milvexian, a novel factor XIa inhibitor, was effective at preventing venous thromboembolism and was linked to a low rate of bleeding, researchers reported.
  • “Factor XIa is an important driver of postoperative VTE,” Weitz said during the presentation.
  • “Postoperative factor XIa inhibition with oral milvexian was effective for prevention of venous thromboembolism and was associated with a low risk of bleeding,” Weitz told Healio.
  • “The safety of milvexian when given on top of dual or single antiplatelet therapy is under investigation in the ongoing AXIOMATIC SSP trial,” he said.
  • “Further studies are needed to determine whether oral anticoagulants targeting factor XIa can dissociate thrombosis from hemostasis.
  • ” Reference: Perspective Back to Top Roxana Mehran, MD This phase 2a study was the first time analyzing preoperative Factor XIa inhibition for VTE prophylaxis.

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