Neurobehavioral phenotypes may identify individuals with TBI at risk for poor outcomes


Sumary of Neurobehavioral phenotypes may identify individuals with TBI at risk for poor outcomes:

  • Qualitatively distinct profiles of symptoms and cognitive functioning in patients with traumatic brain injury may identify those at risk for poor outcomes, according to results of a prospective cohort study published in JAMA Network Open..
  • In this study, we were looking for subgroups of TBI patients that have distinct profiles of clinical signs and symptoms, which we believe will help us develop more personalized treatments for TBI.”.
  • Specifically, Nelson and colleagues sought to assess whether distinct neurobehavioral phenotypes were identifiable 2 weeks after TBI, as well as to determine the extent to which early neurobehavioral phenotypes affect 6-month outcomes..
  • The researchers derived latent profiles using common dimensions of neurobehavioral functioning at 2 weeks after injury, which they evaluated via the NIH TBI Common Data Elements..
  • Satisfaction With Life Scale (SWLS), Quality of Life after Brain Injury-Overall Scale (QOLIBRI-OS), Glasgow Outcome Scale-Extended (GOSE) and Rivermead Post-Concussion Symptoms Questionnaire (RPQ) served as 6-month outcomes..
  • Results of the latent profile analysis showed the following distinct neurobehavioral phenotypes at 2 weeks after injury:…

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