New group of antibacterial molecules identified

new group of antibacterial molecules identified

Sumary of New group of antibacterial molecules identified:

  • Since the properties of the molecules can easily be altered chemically, the hope is to develop new, effective antibiotics with few side effects.
  • Besides the well-known penicillin, that inhibit enzymes building up the wall, newer antibiotics such as daptomycin or the recently discovered teixobactin bind to a special molecule, lipid II.
  • Antibiotics that bind to this cell wall building block are usually very large and complex molecules and therefore more difficult to improve with chemical methods.
  • In this study, researchers at Karolinska Institutet and Umeå University in Sweden have tested a large number of chemical compounds for their ability to lyse pneumococci, bacteria that are the most common cause of community-acquired pneumonia.
  • The initial tests were carried out in collaboration with the Chemical Biology Consortium Sweden (CBCS), a national research infrastructure at SciLifeLab.
  • “The advantage of small molecules like these is that they are more easy to change chemically.

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