Sumary of New information on the early stages of dementia with Lewy bodies:
- In the follow-up study, the researchers utilised a unique Finnish population-based neuropathological dataset (N=291).
- Alpha-synuclein accumulations in the olfactory bulb have not previously been investigated in non-selected population datasets.
- Based on the results, two patterns of accumulations can be identified in the olfactory bulb, with differences seen in their anatomical location and severity.
- “Comparing the findings with the two types of dementia with Lewy bodies defined in our prior study, we noted that the different alpha-synuclein accumulation patterns in the olfactory bulb have a strong association with these two disease types,” Myllykangas says.