New technique uses high-throughput sequencing to obtain ultra-high-resolution images of gene express …

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Sumary of New technique uses high-throughput sequencing to obtain ultra-high-resolution images of gene expression:

  • The difference between a heart cell and a liver cell, for example, is determined by which genes are expressed–and the correct expression of genes can mean the difference between health and disease..
  • A new technique developed by Jun Hee Lee, Ph.D., and his team at the University of Michigan Medical School, part of Michigan Medicine, uses high-throughput sequencing, instead of a microscope, to obtain ultra-high-resolution images of gene expression from a tissue slide..
  • The technology, which they call Seq-Scope, enables a researcher to see every gene expressed, as well single cells and structures within those cells, at incredibly high resolution:.
  • 0.6 micrometers or 66 times smaller than a human hair–beating current methods by multiple orders of magnitude..
  • Related Stories “People have been trying to do this with other methods, such as microprinting, microbeads or microfluidic devices, but because of technological limitations, their resolution has been a distance of 20-100 micrometers..
  • The team demonstrated the effectiveness of the technique using normal and diseased liver cells, successfully identifying dying liver cells, their surrounding inflamed immune cells and liver cells with altered gene expression…

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