Sumary of OCT angiography shows ability to detect subclinical vascular changes in multiple sclerosis:
- Early retinal and choriocapillary vascular changes in multiple sclerosis: A longitudinal study.
- “OCT-A parameters showed retinal vascular abnormalities before the appearance of subsequent neuroaxonal loss,” Daniela Montorio, MD, said.
- In 30 eyes of 15 patients, changes in retinal and choriocapillary vessel density were evaluated on OCT-A over 2 years after an initial demyelinating event (IDE), the first neurological symptom of MS referrable to demyelination in the central nervous system.
- Vessel density reduction was not associated with ganglion cell complex and retinal nerve fiber layer thickness changes, nor with relapse occurrences and MRI activity changes, she said.
- This would confirm the crucial role of retinal vascular impairment in the early stages of MS. “It is possible to hypothesize that a single demyelinating and inflammatory event could cause a retinal hypoperfusion that persists over time.
- This status may initially trigger a vascular compensatory mechanism, which would explain the absence of significant retinal vascular impairment in the first year.
- During the second year of follow-up, persistent inflammation may lead to vascular decompensation, resulting in significant impairment of retinal perfusion,” Montorio said.
- OCT-A has the ability to detect these subclinical vascular changes and confirms to be a useful tool in MS, she said.