Pinpointing how cancer cells turn aggressive

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Sumary of Pinpointing how cancer cells turn aggressive:

  • In a new study, a team led by Simeonov and School of Veterinary Medicine professor Christopher Lengner has made strides toward deepening that understanding by tracking the development of metastatic cells..
  • “By building a precision tool for probing cancer metastasis in vivo, we’re able to observe previously inaccessible types of information,”.
  • the single-cell RNA profiling results underscore that gene expression patterns — which genes cells are turning on and off — play a key role in disease outcomes..
  • In order to better understand the biological changes that accompany metastasis, Simeonov, Lengner, and colleagues aimed to meticulously track this process, using evolving barcoding, also referred to as CRISPR lineage tracing, which enables reconstruction of cell family trees..
  • To track lineage, the researchers developed a new method employing CRISPR/Cas9 to mutagenize synthetically introduced DNA sequences, serving as cellular barcodes….

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