Researchers analyze metrics of cognitive decline in diverse Latinx populations

researchers analyze metrics of cognitive decline in diverse latinx populations

Sumary of Researchers analyze metrics of cognitive decline in diverse Latinx populations:

  • APOE-ε4 is the strongest known genetic risk factor for ADRD , however this finding is largely based on studies of individuals of European descent..
  • To better understand the association of the APOE gene with cognitive decline in Latinx populations, researchers from Brigham and Women’s Hospital and collaborators analyzed metrics of cognitive decline in six diverse Latinx populations:.
  • They found that the APOE-ε4 genetic variant was associated with risk of cognitive decline in Latinx populations, with the strongest effect among those of Cuban backgrounds..
  • Einat Granot-Hershkovitz, PhD, Study First Author and Research Fellow, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital The six Latinx subgroups differ based on what proportion of their genes trace back to African, European, and Amerindian (indigenous American) ancestries..
  • Related Stories “We think proportion of ancestry is a crude measure of genetics, but there are probably specific genetic factors that may be specific to Amerindian ancestry that drive this difference in the effect of APOE,”.
  • The researchers based their findings on 4,183 Latinx individuals participating in the Hispanic Community Health Study/Study of Latinos and the ancillary Study of Latinos-Investigation of Neurocognitive Aging…

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