Sumary of Researchers target a mouse’s own cells, rather than using antibiotics, to treat pneumonia:
- The method involves white blood cells of the immune system called macrophages that eat bacteria, and a group of compounds that are naturally produced in mice and humans called epoxyeicosatrienoic acids or EETs.
- Edin led the team that found infection induces a protein called soluble epoxide hydrolase (sEH) that degrades EETs.
- At the other end of the spectrum, blocking EETs using a synthetic molecule called EEZE boosted the eating capacity of the macrophages, leading to reduced numbers of bacteria in the lungs of mice.
- “These new molecules could be used in an inhaler or pill to promote bacterial killing and make the antibiotics more effective.
- He and his research group determined that EETs provide beneficial cardiovascular effects, such as lowering blood pressure and inflammation, and improving cell survival after a stroke or heart attack.