Scientists explore the creation of artificial organelles

scientists explore the creation of artificial organelles

Sumary of Scientists explore the creation of artificial organelles:

  • These compartments have multiple enzymes that work together to execute important cellular functions.
  • This was achieved through reprogramming of ‘exosomes’, which are small vesicles (diameter ~120 nm) that cells use for intercellular signaling.
  • This allows them to produce high-value biomolecules by performing desired biocatalytic transformations in a spatially confined manner which is not possible using conventional laboratory test tubes.
  • The team demonstrated this multienzyme biocatalytic cascade function by encapsulating glucose oxidase (GOx) and horseradish peroxidase (HRP) inside the exosomes.
  • The cells derived from human breast tissues were fed with fused exosome nanoreactors, and their internalization over the next 48 hours was observed using various markers and a confocal laser scanning microscope (CLSM).
  • Armed with this knowledge, the team sought to create functional artificial mitochondria that are capable of producing energy inside the cells.

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