Scientists harness the naturally abundant CRISPR-Cas system to edit superbugs with the hope of treat …

scientists harness the naturally abundant crispr cas system to edit superbugs with the hope of treating infections caused by drug resistant pathogens

Sumary of Scientists harness the naturally abundant CRISPR-Cas system to edit superbugs with the hope of treating infections caused by drug resistant pathogens:

  • A research team led by Dr Aixin YAN, Associate Professor from the Research Division for Molecular &
  • The research opened a new avenue to genomically edit those wild bacterial species and isolates, such as those with clinical and environmental significance and those forming human microbiome.
  • It also provided a framework to harness other CRISPR-Cas systems widespread in prokaryotic genomes and expand the CRISPR-based toolkits.
  • The research has been published in the leading science journal Nucleic Acids Research.
  • Background CRISPR-Cas system comprises the adaptive immune system in prokaryotes that disarms invading viruses by cleaving their DNA.
  • The method is based on the Class 2 type II CRISPR/Cas9 system, which has revolutionised genetics and biomedical research in a plethora of organisms and was awarded the 2020 Nobel Prize in Chemistry.
  • 10% of the CRISPR-Cas systems encoded naturally in prokaryotes.
  • Remarkably, CRISPR-Cas systems belonging to different classes and types are continuously identified, and they serve as a deep reservoir for the expansion of the CRISPR-based toolkits.

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