Strong signals: Modeling the dynamics of cell differentiation in the development of bile ducts

strong signals modeling the dynamics of cell differentiation in the development of bile ducts

Sumary of Strong signals: Modeling the dynamics of cell differentiation in the development of bile ducts:

  • “A Delta ligand released by a portal vein cell can bind to a Notch receptor to regulate gene expression in the epithelial cell,” first author Masaharu Yoshihara explains.
  • The diffusion of Delta molecules led to concentration differences based on the location, ensuring that epithelial differentiation occurred at only the correct places, which the authors called “fine-grained differentiation.
  • “This project demonstrates the ability of computer models to simulate the formation of spatial structure using complex feedback signaling pathways,” senior author Professor Satoru Takahashi says.

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