Sumary of Study: Age-related changes in brain stem cells are more pronounced in male animals:
- The adult brain constantly generates new brain cells called neurons from stem cells, a process called neurogenesis..
- Related Stories To address this, researchers Sally Temple, PhD ([email protected]), Kristen Zuloga, PhD ([email protected]) and colleagues at the NY Neural Stem Cell Institute, USA, have now compared neurogenic brain regions in male and female mice in a recent study published in Stem Cell Reports..
- The research focused on blood vessels, which are known to regulate brain stem cell activity and to guide the migration of newborn neurons in the brain..
- Further, brain stem cells were less frequent and had less contact with blood vessels in aged male mice compared to female mice..
- Researchers found that although numbers of newly generated neurons were comparable between the sexes, migration of newborn neurons, a process where new neurons move along pre-defined paths to their destination area in the brain, was much more disorganized in aged male mice compared to female mice…