Sumary of Study implicates placental protein as a possible regulator of an infant’s birthweight:
- New findings from the University of Minnesota Medical School are helping uncover why some people are more likely to be overweight and develop Type 2 diabetes — and it starts in the womb..
- Previous association studies have shown that low birthweight among infants is a strong determinant for eventual obesity and Type 2 diabetes..
- Building off of that research, a U of M Medical School study, published in JCI Insight, is the first to directly implicate mTOR, a nutrient-sensor protein in the placenta, as a possible regulator of an infant’s birthweight..
- – After eliminating mTOR in the placenta, female offspring had lower birthweights and had an increased risk for obesity and insulin resistance in adulthood..
- – In contrast, after increasing mTOR signaling in the placenta, female adult offspring were protected from high-fat diet induced obesity..
- “Our hope is that we can identify proteins that we may target therapeutically through maternal health to reduce the prevalence of Type 2 diabetes.”…