Systemic biomarkers show beneficial effects of aerobic exercise on brain function in older adults

514496

Sumary of Systemic biomarkers show beneficial effects of aerobic exercise on brain function in older adults:

  • Increasing evidence shows that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD)..
  • In aging humans, aerobic exercise training increases gray and white matter volume, enhances blood flow, and improves memory function..
  • The ability to measure the effects of exercise on systemic biomarkers associated with risk for AD and relating them to key metabolomic alterations may further prevention, monitoring, and treatment efforts..
  • However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking..
  • They examined myokine Cathepsin B (CTSB), brain derived neurotrophic factor (BDNF), and klotho, as well as metabolomics, which have become increasingly utilized to understand biochemical pathways that may be affected by AD..
  • Researchers performed a metabolomics analysis in blood samples of 23 asymptomatic late middle-aged adults, with familial and genetic risk for AD (mean age 65 years old, 50 percent female) who participated in the “aeRobic Exercise And Cognitive Health (REACH) Pilot Study”.
  • Results of the study, published in the journal Frontiers in Endocrinology, showed that plasma CTSB levels were increased following this 26-week structured aerobic exercise training in older adults at risk for AD..
  • The present correlation between CTSB and verbal learning and memory suggests that CTSB may be useful as a marker for cognitive changes relevant to hippocampal function after exercise in a population at risk for dementia….

Want to know more click here go to source.

From -
Close
Generic selectors
Exact matches only
Search in title
Search in content

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close