Sumary of Systemic biomarkers show beneficial effects of aerobic exercise on brain function in older adults:
- Increasing evidence shows that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD)..
- In aging humans, aerobic exercise training increases gray and white matter volume, enhances blood flow, and improves memory function..
- The ability to measure the effects of exercise on systemic biomarkers associated with risk for AD and relating them to key metabolomic alterations may further prevention, monitoring, and treatment efforts..
- However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking..
- They examined myokine Cathepsin B (CTSB), brain derived neurotrophic factor (BDNF), and klotho, as well as metabolomics, which have become increasingly utilized to understand biochemical pathways that may be affected by AD..
- Researchers performed a metabolomics analysis in blood samples of 23 asymptomatic late middle-aged adults, with familial and genetic risk for AD (mean age 65 years old, 50 percent female) who participated in the “aeRobic Exercise And Cognitive Health (REACH) Pilot Study”.
- Results of the study, published in the journal Frontiers in Endocrinology, showed that plasma CTSB levels were increased following this 26-week structured aerobic exercise training in older adults at risk for AD..
- The present correlation between CTSB and verbal learning and memory suggests that CTSB may be useful as a marker for cognitive changes relevant to hippocampal function after exercise in a population at risk for dementia….