Sumary of Using metal nanoparticles to fight SARS-CoV-2:
- A recent review article looks at the potential of nanotechnology in fighting severe acute respiratory syndrome 2 (SARS-CoV-2), with several possibilities of strategies in therapeutics, vaccines, and prevention.
- The review article, published in the journal Nanomaterials provides insights into recent studies using metal nanocomposites as antivirals.
- In addition to discussing SARS-CoV, middle east respiratory (MERS)-CoV, and coronaviruses, other enveloped and RNA viruses are also included as targets for metallic nanomaterials in this review.
- Among these, SARS-CoV, MERS-CoV, and SARS-CoV-2 cause severe respiratory disease with complex pathophysiology associated with multiple organ failure, sepsis, and death.
- In addition, the fact that the virus uses the host cell machinery for its replication is essential for developing an antiviral drug that does not harm the host.
- Unique size, high surface-to-volume ratio, surface plasmon resonance, and malleable optical absorption spectra of metallic nanoparticles are some of the advantages in using nanotechnology for antiviral strategies – bioconjugation, nanocarriers or drug stabilization, production of hosts reactive oxygen species (ROS), etc.
- Viral components are packed and assembly in a mature virion structure that is then released Metal Nanoparticles as Antivirals Related StoriesMetal nanoparticles can attack multiple viral targets with minimal subsequent resistance development.
- The antiviral and inhibitory activity of AgNPs is shown against TGEV, porcine coronavirus, as a model of CoV and feline coronavirus (FCoV).