World’s first human tracheal transplant performed by Mount Sinai surgeons


Sumary of World’s first human tracheal transplant performed by Mount Sinai surgeons:

  • A team of Mount Sinai surgeons has performed the world’s first human tracheal transplant–an achievement that has the potential to save the lives of thousands of patients around the world who have tracheal birth defects, untreatable airway diseases, burns, tumors, or severe tracheal damage from intubation, including those who had been hospitalized with COVID-19 and placed on a ventilator..
  • Until now, no long-term treatments existed for these patients with long-segment tracheal damage, and thousands of adults and children have died each year as a result..
  • Surgeons have been unable to transplant this organ in large part because of the complexity of providing blood flow to the donor trachea, leaving patients with long-segment tracheal disease no option for treatment..
  • Mount Sinai’s historic procedure resulted from 30 years of research that focused on how to revascularize, or provide blood flow to the trachea, and understanding the biology of the organ..
  • Genden, MD, MHCA, FACS, the Isidore Friesner Professor and Chair of Otolaryngology – Head and Neck Surgery for Mount Sinai Health System and Professor of Neurosurgery, and Immunology, at the Icahn School of Medicine at Mount Sinai..
  • “For the first time, we are able to offer a viable treatment option to patients with life-compromising long-segment tracheal defects, and this development will change the standard of care..
  • It is particularly timely given the growing number of patients with extensive tracheal issues due to COVID-19 intubation..
  • Because of both mechanical ventilation and the nature of the COVID-19-induced airway disease, tracheal airway disease is precipitously increasing, and now we have a treatment..
  • This surgical achievement is not only the culmination of 30 years of research that began when I was a medical student at Mount Sinai, but was also made possible by the spirit of collaboration that exists at Mount Sinai.”.
  • She breathed through a tracheostomy–a surgically created hole in her neck–and was at high risk of suffocation and death because of the progression of her airway disease and likelihood of her trachea collapsing..
  • During the procedure, the Mount Sinai surgical team removed the trachea and the associated blood vessels from the donor..
  • Ultimately, everything went smoothly because we assembled a strong team with extensive surgical expertise in organ transplantation and tracheal reconstruction….

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