Polygenic risk score alone not superior to known risk factors for identifying depression

polygenic risk score alone not superior to known risk factors for identifying depression

January 13, 2021

2 min read


Disclosures: Agerbo reports no relevant financial disclosures. Please see the study for all other authors’ relevant financial disclosures.

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Current polygenic risk scores for depression were not more likely to be linked to major depressive disorder than were other known risk factors, according to results of a case-cohort study published in JAMA Psychiatry.

However, in conjunction with other risk factors, they may be helpful in identifying risk, researchers noted.

Esben Agerbo

“Genetics are, in many ways, exactly like any other risk factors — a high genetic liability does not mean doom, but it merely increases risk,” Esben Agerbo, DrMedSc, of the Centre for Integrated Register-based Research and National Centre for Register-Based Research at Aarhus University in Denmark, told Healio Psychiatry. “Furthermore, it is important to report risk (ie, the probability of depression) and not only odds ratios or risk ratios as previous studies have done. Knowing the actual/absolute risk means that one has a solid foundation for evaluating the importance of a risk factor and knowing what can be expected from an intervention.”…

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