Combinatorial serum protein panel ‘promising’ in early HCC detection

combinatorial serum protein panel promising in early hcc detection

Sumary of Combinatorial serum protein panel ‘promising’ in early HCC detection:

  • November 18, 2021 1 min read Source/Disclosures Published by: Source: Rao S. Tissue and blood-based TGF-B pathway functional biomarkers for early detection of hepatocellular cancer (HCC) in patients with cirrhosis.
  • Back to Healio Use of a transforming growth factor-beta pathway-based combinatorial serum protein panel may aid in the early detection of hepatocellular carcinoma, according to research presented at The Liver Meeting Digital Experience.
  • “Current screening of HCC is based on ultrasound and serum alpha-fetoprotein but it has very limited sensitivity.
  • Ideally, we want our new biomarkers to be easy to use and low cost with high sensitivity and specificity;
  • we are still looking for new biomarkers,” Shuyun Rao, MD, of the Feinstein Institutes for Medical Research and Cold Spring Harbor Laboratory, said.
  • “Our hypothesis is proteomic alteration in the pathological state will reflect a function consequence of ongoing biological abnormality to identify tissue and blood-based proteomic biomarkers with a focus on the transforming growth factor-beta (TGF-B) pathway.
  • ” To identify tissue and blood-based combinatorial biomarker panels that aid in the early detection of HCC, researchers evaluated tissue biomarkers using immunohistochemical (IHC) labeling with artificial intelligence validation against 10 functional biomarkers.
  • They performed bioinformatic and statistical analysis on a targeted set of proteins from the TGF-B pathway to identify serum biomarkers.

Want to know more click here go to source.

From -


Site Language

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.