Combinatorial serum protein panel ‘promising’ in early HCC detection

combinatorial serum protein panel promising in early hcc detection

Sumary of Combinatorial serum protein panel ‘promising’ in early HCC detection:

  • November 18, 2021 1 min read Source/Disclosures Published by: Source: Rao S. Tissue and blood-based TGF-B pathway functional biomarkers for early detection of hepatocellular cancer (HCC) in patients with cirrhosis.
  • Back to Healio Use of a transforming growth factor-beta pathway-based combinatorial serum protein panel may aid in the early detection of hepatocellular carcinoma, according to research presented at The Liver Meeting Digital Experience.
  • “Current screening of HCC is based on ultrasound and serum alpha-fetoprotein but it has very limited sensitivity.
  • Ideally, we want our new biomarkers to be easy to use and low cost with high sensitivity and specificity;
  • we are still looking for new biomarkers,” Shuyun Rao, MD, of the Feinstein Institutes for Medical Research and Cold Spring Harbor Laboratory, said.
  • “Our hypothesis is proteomic alteration in the pathological state will reflect a function consequence of ongoing biological abnormality to identify tissue and blood-based proteomic biomarkers with a focus on the transforming growth factor-beta (TGF-B) pathway.
  • ” To identify tissue and blood-based combinatorial biomarker panels that aid in the early detection of HCC, researchers evaluated tissue biomarkers using immunohistochemical (IHC) labeling with artificial intelligence validation against 10 functional biomarkers.
  • They performed bioinformatic and statistical analysis on a targeted set of proteins from the TGF-B pathway to identify serum biomarkers.

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