Genetic modification in ‘coat’ of fatal brain virus may allow it to escape antibodies

genetic modification in coat of fatal brain virus may allow it to escape antibodies

Sumary of Genetic modification in ‘coat’ of fatal brain virus may allow it to escape antibodies:

  • Genetic mutations in the capsid of JCPyV are common in PML patients and scientists to have struggled to understand whether they allow the virus to infect brain cells or whether the resulting changes allow the virus to evade elimination by antiviral antibodies and then cause brain infection..
  • Related Stories To study how the mutation allows the virus to evade antibodies, the research team, including doctoral student Matthew Lauver and medical scientist training program student Daniel Goetschius, used cryogenic electron microscopy to determine the 3D, atomic-resolution structure of the virus particles bound to monoclonal antibodies…

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