International collaboration secures €1M grant to investigate new treatment target for lymphoma

international collaboration secures e1m grant to investigate new treatment target for lymphoma

Sumary of International collaboration secures €1M grant to investigate new treatment target for lymphoma:

  • An international collaboration involving researchers from Queen Mary University of London, Memorial Sloan Kettering Cancer Center (MSK), New York and Dana-Farber Cancer Institute, Boston has secured a €1M research grant from Dutch blood cancer charity, Lymph&Co, to investigate a new treatment target for lymphoma.
  • The aim of the project is to determine how targeting a protein called KDM5 kills lymphoma cells, and to identify the patient groups most likely to benefit from this type of treatment.
  • Lymphoma is a type of blood cancer that arises from white blood cells called lymphocytes.
  • Changes in the genetic code (mutations) of lymphocytes can cause them to grow uncontrollably and, as a result, these white blood cells collect in lymph nodes and other tissues, eventually giving rise to lymphoma.
  • There are two main types of lymphoma: Hodgkin’s and non-Hodgkin’s lymphoma (NHL), which comprise over 60 subtypes.
  • Combatting the effects of common lymphoma mutations Research has shown that many lymphoma patients have one or more mutations in a gene called KMT2D.
  • The KMT2D gene codes for a protein involved in controlling gene expression within cells;
  • however, mutations that stop KMT2D from functioning correctly (leading to changes in the expression of genes required for normal cell function) are the most common mutations detected in lymphoma.

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