Sumary of Lef1 gene restricts formation of cancer stem cell niches to suppress colorectal tumor growth:
- The new research findings help to understand mechanisms that lead to different types of intestinal tumors.
- They show that the Lef1 gene suppresses the development and growth of colorectal cancer by restricting the formation of cancer stem cell niches.
- In the recent issue of Science Advances, cancer researchers from the iCAN Digital Precision Cancer Medicine Flagship at the University of Helsinki and HUS Helsinki University Hospital report novel research findings on stem cells in benign tumors of the gut, in which colorectal cancer originates.
- They demonstrate that the Lef1 gene suppresses the development and growth of cancer by restricting the formation of cancer stem cell niches.
- The Lef1 gene is induced in tumors known as adenomas in the gut.
- Lef1 gene restricts formation of cancer stem cell niches What makes the report noteworthy is that cancer stem cells are important targets in the treatment of cancer.
- Cancer stem cell niches can support stem cell growth as distinct regions within the tumor microenvironment.
- The investigators found that when expression of the Lef1 gene was blocked, tumor stem cell niches increased, and tumor growth was markedly accelerated.