MR-guided focused ultrasound can safely deliver antibody therapy to Her2-positive brain metastases

mr guided focused ultrasound can safely deliver antibody therapy to her2 positive brain metastases

Sumary of MR-guided focused ultrasound can safely deliver antibody therapy to Her2-positive brain metastases:

  • In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver antibody therapy to breast cancer that has metastasized to the brain.
  • Antibody therapies can help the immune system fight cancer cells, and they are often used in combination with radiation and chemotherapy.
  • However, the BBB presents a challenge when attempting to target sites in the brain.
  • The BBB is a layer of cells lining blood vessels that protects the brain from viruses, bacteria, and other toxins – but it can also prevent therapeutics, such as trastuzumab, from reaching the brain in high enough concentrations to be effective.
  • These are preliminary, but very promising, results that with continued research have implications well beyond brain cancer for other neurological conditions, including Parkinson’s disease and Alzheimer’s, where the blood-brain barrier poses a challenge to drug delivery.
  • ” Related StoriesMetastatic breast cancer, also known as Stage IV breast cancer, starts in the breast and can spread to the brain, bones, liver, or other organs.

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