Sumary of MR-guided focused ultrasound can safely deliver antibody therapy to Her2-positive brain metastases:
- In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver antibody therapy to breast cancer that has metastasized to the brain.
- Antibody therapies can help the immune system fight cancer cells, and they are often used in combination with radiation and chemotherapy.
- However, the BBB presents a challenge when attempting to target sites in the brain.
- The BBB is a layer of cells lining blood vessels that protects the brain from viruses, bacteria, and other toxins – but it can also prevent therapeutics, such as trastuzumab, from reaching the brain in high enough concentrations to be effective.
- These are preliminary, but very promising, results that with continued research have implications well beyond brain cancer for other neurological conditions, including Parkinson’s disease and Alzheimer’s, where the blood-brain barrier poses a challenge to drug delivery.
- ” Related StoriesMetastatic breast cancer, also known as Stage IV breast cancer, starts in the breast and can spread to the brain, bones, liver, or other organs.