Researchers restore function in a gene that can suppress liver cancer and enhance immunotherapy

researchers restore function in a gene that can suppress liver cancer and enhance immunotherapy

Sumary of Researchers restore function in a gene that can suppress liver cancer and enhance immunotherapy:

  • When used in combination with immune checkpoint blockade (ICB), the p53 mRNA nanoparticle approach not only induced suppression of tumor growth but also significantly increased antitumor immune responses in hepatocellular carcinoma (HCC) laboratory models.
  • Immune checkpoint blockers, a revolutionary new class of drugs that enable the body’s immune system to recognize and attack cancer cells, have shown efficacy in treating HCC, but most patients do not benefit.
  • In doing so, they uncovered evidence that p53 regulates the tumor microenvironment by modulating the interaction of cancer cells with immune cells as part of ICB therapy.
  • “In our previous work we had developed nanoparticles to target CXCR4 — a chemokine receptor expressed by liver cancer cells — and selectively co-deliver drugs such as kinase inhibitors,” explains Duda.
  • “We’ve now adapted this platform to use CXCR4 as a kind of ZIP code to selectively target the tumor with nanoparticles encapsulating therapeutic mRNAs.

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