Survivors of Hodgkin lymphoma at risk for long-term cardiovascular toxicities

Sumary of Survivors of Hodgkin lymphoma at risk for long-term cardiovascular toxicities:

  • Back to Healio Some survivors of Hodgkin lymphoma included in the Mass General Brigham YOUNG-MI registry experienced a myocardial infarction before age 50 years, according to a research letter published in JACC: CardioOncology.
  • 2021.04.001. “It is well-known that survivors of Hodgkin lymphoma can develop premature coronary artery disease due to cardiotoxicity from their cancer treatment.
  • We aimed to study this by leveraging the Mass General Brigham YOUNG-MI registry,” Sanjay Divakaran, MD, researcher in the division of cardiovascular medicine and cardiovascular imaging program at Brigham and Women’s Hospital, told Healio.
  • The retrospective cohort study included 2,097 patients who experienced a first type 1 myocardial infarction at or before age 50 years between 2000 and 2016. Investigators sought to assess long-term outcomes of survivors with primary outcomes of all-cause and cardiovascular mortality.
  • They then generated a matched cohort without a history of noncutaneous malignancy who also were included in the registry.
  • Sanjay Divakaran “The results from our study underscore the importance of screening for coronary artery disease among survivors of Hodgkin lymphoma to identify opportunities for primary prevention of coronary artery disease.
  • “We will soon start recruiting survivors of Hodgkin lymphoma in a study involving established and novel cardiovascular imaging biomarkers to better understand the prevalence of coronary artery disease in this population.

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