The micro-environment of breast cancer in three dimensions

332085

Sumary of The micro-environment of breast cancer in three dimensions:

  • Now, Penn State researchers have developed a way to study the relationship between solid, difficult-to-treat tumors and the microenvironment they create to support their growth..
  • The method has the potential to act as a testbed for drugs and other anticancer treatments, according to Ibrahim T..
  • Using metastatic triple-negative breast cancer cells — the most aggressive breast cancer, for which there are few treatments — and specialized modeling techniques, the researchers cultivated tumor microenvironments..
  • “We brought together the tumor and its microenvironment and studied how the embedded tumor affects its surrounding matrix,”.
  • Typically, researchers examine the genetic information of single cells in a system to understand which signals are being sent and received to encourage specific behaviors..
  • “The result was a far more representative understanding of how cells talk to each other in the native conditions.”.
  • They found that the physiological changes in tumor behavior — such as growth or movement — are a direct result of cellular communication in the tumor’s microenvironment..
  • Cancer cells communicate with the cells lining blood vessels, called endothelial cells, that also control the exchange of materials between blood and the extracellular environment..
  • Cancer also communicates with the cells that secrete collagen to produce the scaffolding of tissues, called fibroblasts..
  • To test their approach, the researchers 3D-bioprinted tumor models called spheroids in a microenvironment to see how distance might influence tumor growth..
  • “We asked, ‘Can proximity increase cancer aggressiveness?’ and we found that there is a critical distance,”…

Want to know more click here go to source.

From -
Close
Generic selectors
Exact matches only
Search in title
Search in content

Site Language


By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close