UCLA-developed new “virtual histology” technology may reduce need for skin biopsies

ucla developed new virtual histology technology may reduce need for skin biopsies

Sumary of UCLA-developed new “virtual histology” technology may reduce need for skin biopsies:

  • Images appear like biopsied, histochemically stained skin sections imaged on microscope slides,” said the study’s senior author, Aydogan Ozcan, Chancellor’s Professor and Volgenau Chair for Engineering Innovation of the Electrical and Computer Engineering Department at UCLA Samueli.
  • Previously, this technology has only been applied to microscopy slides that contained unstained tissue, acquired through a biopsy.
  • It also can be costly for patients and the health care system,” said Dr. Philip Scumpia, assistant professor of dermatology and dermatopathology at the David Geffen School of Medicine at UCLA and the West Los Angeles Veterans Affairs Hospital and a member of the UCLA Jonsson Comprehensive Cancer Center.
  • “Our approach potentially offers a biopsy-free solution, providing images of skin structure with cellular-level resolution.
  • Laser Centre in Los Angeles, created a deep-learning framework to transform images of intact skin acquired by an emerging noninvasive optical technology, reflectance confocal microscopy (RCM), into a format that is user-friendly for dermatologists and pathologists.
  • Analyzing RCM images requires special training because they are in black and white, and unlike standard histology, they lack nuclear features of cells.
  • Related Stories”I was surprised to see how easy it is for this virtual staining technology to transform the images into ones that I typically see of skin biopsies that are processed using traditional chemical fixation and tissue staining under a microscope,” Scumpia said.
  • The researchers trained a “convolutional neural network” to rapidly transform RCM images of unstained skin into virtually stained 3D images like the H&E (hematoxylin and eosin) images familiar to dermatologists and dermatopathologists.

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