Sumary of Dental implant surfaces play major role in tissue attachment, warding off unwanted bacteria:
- The implants adsorb a thin layer of proteins from these fluids that help gum tissue attach, but also allow microorganisms — including potentially harmful bacteria — to grow on the implant surface.
- The research, published in the Journal of Dental Research, sought to increase scientists’ understanding of this complex biological process by examining the makeup of the oral protein layer and how it can be controlled by chemically modifying the biomaterial surface.
- “It is often this protein layer, rather than the biomaterial surface, that is encountered by colonizing bacteria or attaching tissue cells.
- Using silica beads designed in Müller’s lab with various chemically modified surfaces, the researchers found that the adsorption of proteins from blood plasma is more influenced by the amount of protein adsorbed than by the composition of the protein layer.
- Adsorption was lower on surfaces that had a negative electric charge or that repelled water, countering the findings of previous studies.
- ” The model system of chemically modified silica surfaces developed by the researchers may serve as a platform to study the basic principles of protein adsorption from complex biofluids.