Sumary of SARS-CoV-2 genomic surveillance identifies intricacies of stabilizing vs. destabilizing mutations:
- The rapid outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for millions of infections and deaths worldwide.
- However, the continual emergence of SARS-CoV-2 variants has called into question the efficacy of the available vaccines.
- Some of these variants, known as variants of concern (VoC), have a much higher rate of transmission and increased mortality than the original SARS-CoV-2 strain.
- Therefore, it is imperative to assess the efficacy of the available vaccines against the circulating SARS-CoV-2 strains.
- In addition, tracking the continuously evolving genetic variants is also vital to prevent future outbreaks.
- Tracking the evolution of transmissibility and virulence of SARS-CoV-2 The evolution of transmissibility and virulence of SARS-CoV-2 has occurred due to functional mutations.
- Therefore, evaluating the changes in the genetic sequences is vital to determine the evolutionary distance and stability of SARS-CoV-2 variants from the sequence of the original strain isolated in Wuhan.
- Owing to the availability of the whole-genome sequences of the virus in public repositories, such as the Global Initiative on Sharing All Influenza Data (GISAID), and the collection of open-source tools for instantaneous visualization of the genetics behind the virus outbreak, e.