Sumary of Antibody combinations may be more effective at preventing, treating COVID-19:
- Reviewed by Emily Henderson, B.Sc.Nov 19 2020 Pairs of antibodies may be more effective than single antibodies at preventing and treating COVID-19, according to a new study by researchers at the University of North Carolina at Chapel Hill and The Rockefeller University in New York..
- The study, published November 19 in the Journal of Experimental Medicine (JEM), also suggests that in addition to blocking SARS-CoV-2’s entry into cells, the antibodies may combat the virus by enlisting various types of white blood cells to fight the infection..
- Human antibodies that neutralize SARS-CoV-2 hold great potential for preventing and treating COVID-19, and researchers have identified several potent antibodies that bind to the spike protein on the virus’s surface, thereby preventing it from mediating the virus’s entry into cells..
- However, the neutralizing activity of antibodies to SARS-CoV-2 has primarily been tested using cells cultured in the laboratory, and how these in vitro results translate to protection in animals or humans has not been determined.”.
- Sheahan, Assistant Professor, Gillings School of Public Health at the University of North Carolina at Chapel Hill Related Stories Research teams led by Sheahan and co-lead author Michel C..
- Nussenzweig, who is a professor, investigator, and senior physician at The Rockefeller University and Howard Hughes Medical Institute, tested the ability of several human antibodies to prevent SARS-CoV-2 infection in mice or hamsters..
- Some antibodies that were relatively poor at blocking viral entry into cultured cells were much more effective at preventing SARS-CoV-2 infection in rodents..
- The researchers determined that this is partly because, in addition to blocking viral entry, the antibodies can activate various types of white blood cells….