Sumary of COVID-19 vaccine boosters to prevent breakthrough SARS-CoV-2 infections in healthy adults:
- Study: Antibody titers before and after booster doses of SARS-CoV-2 mRNA vaccines in healthy adults.
- 1.617.2 (Delta) variant increased due to the weakening immunity, thus resulting in a higher number of COVID-19 cases in the summer of 2021. The sudden increase in infections prompted the U.S. regulatory approval of booster vaccines for higher-risk individuals.
- The participants provided finger stick dried blood spot samples before booster administration and 6-10 days after being vaccinated with the booster dose.
- The previous community-based study measured the antibody responses after SARS-CoV-2 infection or after receiving the second dose of the mRNA vaccine.
- Study findings The data obtained from the study showed that the antibody responses after 6-10 days of receiving the booster dose are greater than natural infection with SARS-CoV-2, after two doses of the mRNA vaccine, and after both natural infection and vaccination.
- Further, the SARS-CoV-2 Delta variant showed high surrogate neutralization;
- however, this neutralization response was still lower than that following exposure to the wild-type SARS-CoV-2 strain.
- No differences were observed for SARS-CoV-2 Delta variant neutralization in females and males;