CRISPR scientists claim they identified human genes that can protect against Covid-19

crispr scientists claim they identified human genes that can protect against covid 19 scaled

Sumary of CRISPR scientists claim they identified human genes that can protect against Covid-19:

  • A team of CRISPR scientists at the New York Genome Center, New York University and Icahn School of Medicine at Mount Sinai say they have identified the genes that can protect human cells against Covid-19, a disease that has infected over 40 million and led to 1 million deaths worldwide..
  • The discovery comes after an eight-month screen of all 20,000 genes in the human genome led by Dr. Neville Sanjana at the New York Genome Center..
  • After intensive research the scientists and doctors claim they have found 30 genes that block the virus from infecting human cells including RAB7A, a gene that seems to regulate the ACE-2 receptor that the virus binds to and uses to enter the cell..
  • The team discovered that the top-ranked genes — those whose loss reduces viral infection substantially — clustered into a handful of protein complexes, including vacuolar ATPases, Retromer, Commander, Arp2/3, and PI3K..
  • “We were very pleased to see multiple genes within the same family as top-ranked hits in our genome-wide screen..
  • This gave us a high degree of confidence that these protein families were crucial to the virus lifecycle, either for getting into human cells or successful viral replication,”.
  • Using proteomic data, they found that several of the top-ranked host genes directly interact with the virus’s own proteins, highlighting their central role in the viral lifecycle..
  • The team also analyzed common host genes required for other viral pathogens, such as Zika or H1N1 pandemic influenza..
  • In particular, they found three drugs currently on the market were more than 100-fold more effective in stopping viral entry in human lung cells:…

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