DNA on-off switches for SARS-CoV-2 host receptor as potential therapeutic targets

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Sumary of DNA on-off switches for SARS-CoV-2 host receptor as potential therapeutic targets:

  • Within the angiotensin-converting enzyme 2 (ACE2) gene that may control the expression of this host cell receptor before, during and after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)..
  • The SARS-CoV-2 virus is the agent responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic that has caused 174 million infections and more than 3.76 million deaths globally since the outbreak began in late December 2019..
  • The human ACE2 receptor is the main host cell structure that the SARS-CoV-2 surface spike protein binds to as the initial stage of the infection process..
  • “Our work supports the further pursuit of these putative mechanisms in our understanding, prevention, and treatment of infection and disease caused by ACE2-utilizing viruses such as SARS-CoV, SARS-CoV-2, and future emerging SARS-related viruses,”.
  • More about the ACE2 receptor and SARS-CoV-2 infection The ACE2 protein is a key catalytic regulator of the renin-angiotensin system (RAS) that controls blood pressure and maintains fluid homeostasis..
  • Changes in ACE2 expression following viral infection can lead to an imbalance in RAS signaling and contribute to the development of clinical symptoms such as excessive inflammation, myocardial injury, and lung injury..
  • c) Pearson correlation of ACE2 with important interferon-related candidate genes found to be co­expressed with ACE2..
  • Little is known about how ACE2 is turned on or off at the DNA level Although great research efforts have been made to understand how SARS-CoV-2 interacts with ACE2, little is known about how ACE2 is turned on or off in human cells at the DNA level….

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