Sumary of Eldelumab and Fenofibrate show potential for COVID-19:
- Based on computational analysis, researchers have discovered multiple drugs that target specific genes and pathways altered in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and had the potential to be potential treatments..
- Although the COVID-19 has been raging around the globe for more than a year, there are have been few drugs found that are effective against the disease..
- Repurposing drugs already approved to treat other diseases can significantly cut down the time to develop new treatments for the disease..
- Analyzing differentially expressed genes from RNA-Seq can help us better understand the infection process and find drugs that can be repurposed..
- In a new study posted to the medRxiv* preprint server, researchers from the University of Pittsburgh and Barrow Neurological Institute report the results of their analysis of several RNA-Seq studies and used computational approaches to discover potential drugs against COVID-19..
- Computational analysis Researchers searched the CLC Genomics Workbench database for RNA-Seq data for SARS-CoV-2..
- They next obtained drug information and mechanism of action from a commercial drug database and when used in combination with all the known genes involved in COVID-19, to come up with a list of possible drug candidates..
- Their analysis revealed 283 differentially expressed genes and pathway analysis identified 27 diseases and disorders, 21 cellular and molecular functions, and 275 general pathways….